Month: March 2009

  • Ada Lovelace Day: Temple Grandin and the True Nature of Nerds

    People walking by my cubicle often pause and look at a picture hanging on my wall. It’s of an old lady in what looks like a meter maid’s uniform. Who is she? Why is this picture so important to you? – they ask.

    The picture, of course is of one of the two patron saints of software developers, Rear Admiral Murray Grace Hopper. Admiral Hopper is an old school hacker, mother of Cobol, popularizer of the term “bug”. There is a missile destroyer named after her, her personal motto is very close to my heart, and she looks a little bit like my grandmother (who happened to be a mechanical engineer).

    The second prominent woman in software is Augusta Ada King, Countess of Lovelace, and a celebration of her life is the reason I am writing this post. Countess Lovelace is famous for grokking what computer programming was all about back in Victorian era, and therefore is often reffered to as the first programmer. If I’ll ever make it out of a cube into an office, I’ll comission an oil portrait of Ada Lovelace and hang it there.

    There aren’t many accomplished women in technology as these two, so someone came up with an idea of celebrating Ada Lovelace’s birthday by getting people to write blog posts that will draw attention to women excelling in technology. I chose to write about Temple Grandin. I would have written about my grandmother, but unfortunately I don’t know much about her life’s work.

    I learned about Temple Grandin from an article in Wired magazine called “The Geek Syndrome“. It was an article about an explosion of cases of autism and Asperger’s syndrome in hotbeds of technology such as Silicone Valley. This article and Temple Grandin’s books, “Thinking in Pictures” and Emergence: Labeled Autistic made me see myself and other techies in a completely different light. I am convinced that some level of autism is what makes people get involved in technology. Being a geek is a bit like having homosexual sex: anybody can do it, very few try it, and only a minority enjoy it and are good at it.

    According to wikipedia “the word geek is a slang term, noting individuals as “a peculiar or otherwise odd person, especially one who is perceived to be overly obsessed with one or more things including those of intellectuality, electronics, etc.”[1] Formerly, the term referred to a carnival performer often billed as a wild man whose act usually includes biting the head off a live chicken, bat, snake or bugs.” Indeed, geeks are strange people. They obsess about things, they have unusual interests, they are incredibly detail-oriented. All of these traits are considered by psychologists to be symptomes of Autistic Spectrum Personality disorder or ASD. “Impaired social interaction and communication” – another geeky/autistic trait.

    “The prevalence of ASD is about 6 per 1,000 people, with about four times as many boys as girls” – also, according to Wikipedia. Eerily, this seems to be more or less in line with overall percentage of people involved in technology and the male/female ratio.

    A human mind is a self-aware and self-adjusting multi-level software/hardware combination, and that makes it very hard to talk about the nature of brain disorders. Autism is particularly tricky: it is a spectrum. People with autism range from those severely afflicted and non-verbal through hundreds of different gradations to a geek with strange hobbies and social interaction problems. Yet it is the same basic thing: some kind of overdevelopment of some areas of the brain and underdevelopment in others, as well as a difference in processing sensory input.

    Temple Grandin started out a severely afflicted autistic child, pretty close to the upper end of the scale. She recoiled from being hugged, started speaking very late, had all kinds of behavioral problems. Even with her high IQ nobody expected her to become a very succesful professional. She was lucky in having parents who sent her to a specialized school, and some teachers who channeled her obsessions into productive direction. She describes herself as a “recovering autistic.”

    Her professional success is tremendous. She became a foremost expert in livestock handling equipment. Before her the livestock industry did not pay a lot of attention to the way animals were handled and transported. Existing structures used to shuffle livestock from a place to a place had design flaws that would cause animals to balk and refuse to move. This caused unnecessery use of force, stressing the animals and their handlers, costing farmers and processors a lot of time and money. Temple Grandin’s attention to detail allowed her to figure out very subtle causes of animal’s discomfort (autistic people are frequently bothered by minute changes in their environment) and figure out better ways to handle them. It’s very likely that all of us at some point drank milk or ate a steak from a cow that went through a facility designed by Dr. Grandin.

    Autism seems to be a hardware-based disorder, something to do with neuron distribution and signal sensitivity. The curious part about problems like that is that they sometimes can be fixed with a software patch and changing some external factors. For instance, if you have a defective computer processor that starts generating errors from overheating, you can fix it by writing error-checking software and cooling it down with a fan.

    After seeing a squeeze chute used to calm down cattle, Temple Grandin ivented a so-called hug machine, a device that applies a deep body pressure and through it makes autistic people feel better.

    In his book Jpod, Douglas Coupland describes how one cubicle dwelling game developers builds a hug machine. After some ridicule and a few tryouts the machine attracts a long line of software developers wanting to use it. I wonder if any of the Google offices have one. I, personally, find that taking a long bath or wrapping very tigtly in a blanket always calms me down. Even better is diving: I get an unusual sense of calm from it.

    Dr. Grandin’s books opened my eyes to the traits of “engineer’s affliction” and allowed me to better understand myself and my fellow geeks. Here’s a short list of the autistic traits that you might find in most software developers:

    * Liking to create lists
    * Lack of eye contact
    * Stimming: repetitive behaviors like rocking in a chair
    * Strange patterns of speech
    * Ranting, long speeches about obscure topics
    * Excruciating attention to detail
    * Love of routine, dislike of change
    * Love of symbols
    * Obsessions with obscure things
    * Superior pattern recognition
    * Visual thinking
    * Liking things more than people
    * Bouts of anxiety, especially in social situations

    Wired has a test designed by Simon Baron-Cohen (Borat’s brother) – you can see how many typical autistic traits you have. My score is 31.

    The good part is that autistic obsessions can be “cashed in” for professional success in technological fields. Think about the level of obsession or concentration necessary to design a computer processor like this one? On the other hand, Dr. Grandin’s books showed me that it is possible to work on problematic traits, like eye contact and social awkwardness. Human minds are strange loops, capable of understanding, rewriting and fixing themselves.

    Here’s a list of books that I recommend for better understanding of techies, male and female:

    * Thinking in Pictures: And Other Reports from My Life with Autism and Emergence: Labeled Autistic by Temple Grandin

    * Jpod and Microserfs by Douglas Coupland

    * A Spot of Bother and The Curious Incident of the Dog in the Night-Time by Mark Haddon.

  • Keep It Under Your Hat

    Thanks to John Kennedy the only people who wear hats these days are hipsters and cops. Hipsters do it ironically and cops have to. Cops don’t particularly like wearing hats, and the hats even have a special loop for attaching them to a belt carabiner.

    NYPD duty hats have a special little pocket in the lining. Over the years I noticed many interesting items in there: icons, shopping lists, wanted posters, family photos. By far the most common is this little card featuring Archangel Michael, the patron saint of law enforcement.

    It seems to be this particular holy card with a prayer on the back. Interesting to note that in Guido Reni’s painting from which this card was made, Michael holds a chain instead of a scale, his cape is pink, hair is longer, there are pink ribbons in his outfit, and there’s a very prominent nipple showing.

  • A review of personal genomics profile from 23andme

    What do I buy: a cleaning robot, an e-ink powered ebook, or a personal genetic test from 23andme.com? This is one of those terrible trilemmas facing geeks who are not willing to sacrifice financial stability for having all the coolest gadgets. I chose a 23andme test, and haven’t regretted it.

    The factoid that always is mentioned in the press about 23andme is that its co-founder Anne Wojcicki is married to Google co-founder Sergey Brin. This of course means that the data that 23andme is collecting is going to be used to help Google’s Skynet to gain the upper hand in the forthcoming war.

    23andme’s service works like this: you give them some money (at the time when I write this the price is $399, but it used to be over $800), they send you a test tube into which you spit, some special preservative solution, and a return envelope. You follow some simple instructions and send your spit to a processing facility. Then you wait (this is the hard part). In a month or so (it depends how long the backlog of orders is) you recieve an email telling you that you can log into 23andme.com and take a look at the results.

    The processing that they do in the lab creates a data file that represents an impressive number of genetic data points called SNPs or single-nucleotide polymorphisms. The way I understand it, SNPs are known variations that happen in DNA sequences. Much of the DNA stays the same for all people, but there are some variations in a single location. Let’s say there’s a string of DNA in humans that goes

    G-A-T-T-A-C-A
    C-T-A-A-T-G-T

    and 6 positions there are the same for everyone, except the seventh, which is sometimes AT and sometimes GC. So basically it’s a single position on the one of the 23 chromosomes or mitochondrial DNA (I guess 23andmitochondriaandme was shot down as a possible name for the company) that statistically is different from person to person as opposed to long stretches of DNA that stay the same.

    Scientists all over the world are studying the correlations that SNPs have with disease risks and traits. I guess these studies go something like this: you grab 500 programmers that use emacs editor and 500 that use vi. You have a hunch that editor preference is related to gene C4711. You sequence the dna of all your coders looking for SNPs in the gene C4711 that are one way in your vi-using alphas and another way in emacs-using sub-omegaloids. Then you find that in most of vi users SNP rs1729 is AA. Then you come out and say – AA in s1729 increases the odds of a programmer preferring vi by 47%.

    The more people that a study has – the better the results. 23andme has genetics experts on staff that sift through mountains of these studies, rank them, and then tell the website people to add results to the interface. This way you can go to 23andme.com and see (as of right now) that tell you right away what your lifetime chances of getting 10 diseases. Some, like Parkinson’s, they don’t let you see without you agreeing to see it yourself. Sergey Brin was reported in the media to get some bad news from that particular one (mine came back “Typical Risk” which means that my chance of getting Parkinson’s is about 1.6%, same as everybody else).

    A lot of people that I talked to about genetic testing told me that they’d “rather not know”. It’s true that some of the things that you might learn will make you worry without being able to do anything about it. On the other hand, there are some that you might be able to do something about.

    “24.1 out of 100 people of European ethnicity who share this genotype will get Prostate Cancer between the ages of 35 and 79” vs “17.8 out of 100” on average. Here I learned that I have about 1 in 4 chance of getting prostate cancer. Prostate cancer is one of the relatively treatable ones if caught early, but with unpleasant diagnostic procedures. All of a sound “digital exam” does not sound so bad, and I guess I’ll have to bend over and cough a lot more often than I otherwise would. I’m not sure what coughing does, but the “digital” part has nothing to do with electronics or numbers.

    There are also 10 traits that are available right now. The most interesting one for me was “Resistant to infection by the most common strain of HIV people usually encounter, though protection is not complete”. I apparently have two copies of something called “Delta32 version of CCR5”. “Although people with two copies of Delta32 are highly resistant to the most common type of HIV, they can be vulnerable to strains of the virus that do not use CCR5 to enter immune cells”.

    This makes me a little bit more at ease when I donate blood, even though I know that the chances of getting infected with AIDS at a blood donation are already less than winning that Mega jackpot. On the other hand Dr. Asimov died of AIDS that he received through a transfusion. What’s more interesting, is that this is the same mutation that prominently figured in the media with the AIDS patient who was cured through a bone marrow transplant.

    Then there’s a section that has 79 research reports. These get a rating fоr “research confidence”. I, for instance, have an elevated risk of obesity from research that has a three star rating.

    Doctor House would have loved getting access to this kind of data for every one of his patients. There are risks for rare diseases mentioned on the show Ankylosing spondylitis, Hemochromatosis, Bloom’s syndrome, and everybody’s favorite – Lupus (which it’s never).

    One of the tests included in 23andme is for muscle performance, the one that was in newspapers lately because it was offered by a few companies. The news angle was that sports obsessed parents paid hundred of dollars to find out if their kids have sprinting or marathon ability. Mine says: “One working copy of alpha-actinin-3 in fast-twitch muscle fiber. Many world-class sprinters and some endurance athletes have this genotype.” This sounds plausible – for a fat dude I have an uncanny ability to sprint, yet suck at long distances.

    But wait, this is not all. For the same low price you also get some ancestral info. This comes in a form of maternal and paternal haplogroup. I am not sure I understand the what haplogroup is very well, and found 23andme’s infographics somewhat confusing. From what I understand a haplogroup is a number that is attached to a certain mutation (a few SNPs maybe?) that arose thousands of years ago and that has been statistically crosslinked to people living in certain geographical locations.

    My paternal haplogroup is E3b1c1* – “populations: Ethiopians, Jordanians, Ashkenazi and Sephardic Jews”. My maternal haplogroup is H5a* – “populations: Lebanese, Polish, Irish”. Both of my ancestral branches are supposedly Ashkenazi, and I guess haplogroups are not a high enough resolution to prove or disprove Jewish ancestry. All they do is tell you that the progeny of your very remote ancestor was likely found in certain wide geographic locales “before the era of intercontinental travel.” What’s interesting is that there’s a small chunk of my maternal haplogroup’s population in Siberia.

    23andme is a true Web 2.0 service (in the good sense of that expression). There’s a blog called The Spittoon. In between educational (sometimes interesting, sometimes boring) posts about genetics they have a section called “SNPwatch“. There they write about new research and usually provide a link to raw data in your 23andme profile. So for instance there was an article titled “Variants in Genes for Carcinogen Transporters Linked to Lung Cancer” about a mutation that prevents lungs from clearing out cancer-causing chemicals. Then you can click on two links and see if you have that mutation (to my relief I don’t).

    There are some social network features: you can compare your DNA profile to your relatives. I’m not sure if hilarity might ensue because I think you can figure out possibility/impossibility of paternity and maternity, like Dr. House did in that episode. You can even compare your DNA to other users of 23andme – you have to accept a “friend” request for that. I’m not really sure what’s the fun in that. You can participate in surveys that might be used for research (there isn’t one yet about vi vs. emacs yet, but there are some other ones).

    It does not look like the $400 fee even covers the cost of gathering the data (there no further fees as of now) or paying for staff/website maintenance, and ongoing research. I’m not really sure what the business model here is (and that makes me a little nervous. Businesses like this remind me of an old Yiddish joke:

    Moyshe is selling boiled chicken eggs. He buys them for a kopek each and sells them for a kopek each. Chaim asks – “Moishe – where’s the profit in this?” “What, are you stupid?” – answers Moyshe. “I get to keep the broth”.

    My guess is that the “broth” here is an opportunity to conduct groundbreaking research and maybe sell the anonymized data. That, and helping Google’s Skynet find and assassinate John Connor.

    I don’t really worry too much about being denied insurance in the grim meathook future that surely is coming just because I used 23andme. There’s legislation against that on the books right now, and if insurance companies will be able to deny coverage based on genetics they’ll be much more likely to get this info by requiring a blood test.

    I really wish I could get the data from my grandparents (none of whom are sadly alive). I will buy kits for my entire family though as soon as I’ll be willing to part with another chunk of disposable income (I do want that dang Kindle first though).

  • National Air And Space Visit

    While in Washington, I visited the National Air and Space Museum. It is like some kind of Lovecraftian Costco warehouse filled with a mix of priceless artifacts encased in layers of plexiglas and cheezy recreations, carnival-like educational attractions, and disguasting food courts and kiosks.

    Overhead, like beached whales or a giant boy’s toy models, hang famous air and space ships. They have just about everything you could think of – Spirit of St. Louis, Space Ship One, a Brietling Orbiter, even the original Wright Flyer. They all look lifeless and sad, especially the spacecraft.

    I was a bit overwhelmed by the craft collection, but it’s the little things that I enjoyed seeing the most. They have, side by side, Nestler sliderules that used to belong to former z/k Korolev and former Sturmbannfuhrer Von Braun. Missing is the Nestler that used to belong to Albert Einstein. I also wonder who now owns the two two-copek coins that were Korolev’s lucky charm. I also wonder if Von Braun used to have a lucky charm.

    The only remaining piece of the original Sputnik – an arming device that was removed prior to launch, an equivalent of little strips of paper you sometimes find in remote controls and other battery-powered gadgets.

    It was interesting to notice how many aircraft were put together using slotted instead of philips screws, like these huge ones on the Soviet ICBM.

    I don’t know why, but I stood for a good while admiring the hypnotic twists of a handmade screwdriver that used to belong to Charlie Taylor, Wright’s mechanic.

    Soviet space kitch collection is vast: from magnetic Mir-flown chess (something of a 70s vintage space look to them)

    to all kinds of space crappers (a low-tec suction bulb is probably safer where your privates and vaccuum are involved).

    The nose cone from the Spirit of St. Louis is signed on the inside, but you have to cram yourself into an uncomfortable niche to see the swastika and signatures of well-wishers, including Wrong Way Corrigan. Apparently early aviators frequently used not yet befouled by Nazis swastikas as good luck charms.

    One of the last things I saw, a crazy looking British pusher airplane had such an amazing Star Wars look that I maybe even gasped a little.